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近年认为右心房心肌细胞内的颗粒释出一种舒张血管和利钠的物质,最近认为它与152个氨基酸多肽前体衍生物21—26氨基酸肽有密切关系,这些肽称心房利钠因子(ANF),ANF的作用机理尚有争论。有人认为它增加肾脏溶质的排泄主要是改变了血流动力学特别是增加肾小球滤过率(GFR),也有人认为肾脏作用不是通过改变GFR而是通过血流的再分配或直接抑制近端小管、髓袢或集合管的重吸收作用。本研究的主要目的阐明用纯合成肽。在血容量正常动物中ANF的肾作用机理,用微穿刺技术测定单个肾单位的GFR以及近端小管和髓
In recent years, it is believed that particles in the right atrial cardiomyocytes release a substance that relaxes blood vessels and sodium, and is recently thought to be closely linked to the 21-26 amino acid peptide, a precursor of a 152 amino acid polypeptide, which is referred to as atrial natriuretic factor ANF), ANF mechanism of action is still controversial. Some people think that it increases renal solute excretion mainly changes the hemodynamics, especially increased glomerular filtration rate (GFR), some people think that the role of the kidney is not by changing GFR but by redistribution of blood flow or direct inhibition of End tubules, medulla or collection tube reabsorption. The main purpose of this study illustrates the use of pure synthetic peptides. The renal mechanism of ANF in normal blood volume animals was assessed by micro-puncture technique for measuring GFR of individual nephrons and proximal tubules and medulla