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目的探索盐酸吡格列酮对煤工尘肺合并2型糖尿(T2DM)患者β细胞功能的影响。方法在煤工尘肺2型糖尿病和非煤工尘肺2型糖尿病原口服抗糖尿病药物方案不变的基础上联合盐酸吡格列酮治疗,连续观察12周,前后对比研究。结果联合方案治疗后血糖(空腹、餐后2h)、糖化血红蛋白(HbA1C)、胰岛素抵抗指数(Homa-IR)明显下降(P<0.05),胰岛素β细胞功能指数(Homa-β)、胰岛素敏感指数(Homa-ISI)较前明显升高(P<0.05)。非尘肺糖尿病组疗效较煤工尘肺并2型糖尿病组好,但组间比较,差异无统计学意义。结论盐酸吡格列酮能提高煤工尘肺合并2型糖尿病患者的Homa-β和Homa-ISI,降低其IR。疗效确切,值得临床推广使用。
Objective To explore the effect of pioglitazone hydrochloride on β-cell function in patients with pneumoconiosis complicated with type 2 diabetes mellitus (T2DM). Methods The combination of pioglitazone hydrochloride and pioglitazone hydrochloride on the basis of the unchanged oral antidiabetic drug regimen of coal worker’s pneumoconiosis type 2 diabetes and non-coal worker’s pneumoconiosis type 2 diabetes mellitus was continuously observed for 12 weeks and compared before and after. Results After treatment, the blood glucose (HbA1c, Homa-IR), Homa-β, insulin sensitivity index (HbA1C) and insulin sensitivity index (Homa-ISI) was significantly higher than before (P <0.05). The efficacy of non-pneumoconiosis diabetic group was better than that of coal worker’s pneumoconiosis and type 2 diabetes group, but there was no significant difference between the two groups. Conclusion Pioglitazone hydrochloride can improve the Homa-β and Homa-ISI of coal worker’s pneumoconiosis patients with type 2 diabetes and reduce their IR. Efficacy, it is worth promoting the use of clinical.