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目的 了解重庆地区宫颈癌、宫颈炎发病与16型人乳头状瘤病毒（HPV16）E6、E7的关系。 方法 运用PCR，分子生物学技术进行HPV16 E6、E7的扩增和克隆。结果 重庆地区宫颈癌、宫颈炎组织中HPV16 E6,E7总检出率分别为70%和65%。 结论 重庆地区HPV16感染与宫颈癌、宫颈炎的发生相关。E7原癌蛋白可能与宫颈癌发生早期有关，而E6原癌蛋白可能与宫颈癌形成晚期关系密切。
Objective To understand the relationship between cervical cancer and cervicitis in Chongqing and the E6 and E7 of human papillomavirus type 16 (HPV16). Methods PCR and molecular biology techniques were used to amplify and clone HPV16 E6 and E7. Results The total positive rates of HPV16 E6 and E7 in cervical cancer and cervicitis in Chongqing were 70% and 65% respectively. Conclusion HPV16 infection in Chongqing is related to the occurrence of cervical cancer and cervicitis. E7 oncogene protein may be related to the early cervical cancer, and E6 oncogene protein may be closely related to the formation of advanced cervical cancer.