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本文综述了 FHF 时的血凝障碍及其处理原则。主要内容包括在 FHF 时血小板质和量的异常及其功能改变,凝血因子的变化,血凝抑制剂 AT-Ⅲ的生理作用及其在 FHF 时含量的改变,纤维蛋白溶解作用和低水平 DIC 的发生。介绍了以凝血酶原时间作为临床肝功能衰竭时估计血凝障碍的一个重要参数。最后对肝功能衰竭时血凝障碍的处理原则、防治出血倾向的各种措施以及肝素在低水平DIC 时的应用进行了讨论。
This article reviews the principles of coagulation disorders and their management at FHF. The main contents include abnormalities and changes of platelet quality and quantity during FHF, changes of coagulation factors, the physiological role of the hemostatic inhibitor AT-Ⅲ and its changes in FHF content, fibrinolysis and low level of DIC occur. The prothrombin time as an important parameter for estimating hemagglutination in clinical liver failure is introduced. Finally, the treatment of hepatic failure, the principle of coagulation disorders, prevention and treatment of bleeding tendency of various measures and the application of heparin at low levels of DIC were discussed.