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国内外曾报告5对孪生兄弟或姐妹同患鼻咽癌.本室最近在进行鼻咽癌高发家系调查中发现一对孪生子鼻咽癌,现报告如下: 宋某两挛生兄弟,男48岁,汉族,广西防城县农民。临床资料见附表。流行病学资料:孪生鼻咽癌患者自小一起居住,无特殊嗜好史和接触史,过去一般健康。家族史中母亲于1978年因患鼻咽癌死亡。居住地带属丘陵小山村,与越南隔江易水,操客家话。讨论①本室曾报告鼻咽癌的家族聚集性现象,在癌家族成员中以兄弟姐妹同患鼻咽癌较多,这对孪生鼻咽癌兄弟属于这一范畴。此外,其母亲也患鼻咽癌,这是否与显性遗传相关,有待进一步研究。②这对孪生子鼻咽癌的临床症状及检查结果大致相
At home and abroad, 5 pairs of twin brothers or sisters have been reported to have nasopharyngeal carcinoma. This laboratory recently found a pair of twin nasopharyngeal carcinomas in a high-risk family survey of nasopharyngeal carcinoma. The report is as follows: Song, two twin brothers, male 48 years old, Han nationality, farmers in Fangcheng County, Guangxi. See clinical data in the attached table. Epidemiological data: Patients with twin nasopharyngeal carcinomas lived together since they were young, with no history of special hobbies and exposure history. They used to be generally healthy. In her family history, her mother died of nasopharyngeal cancer in 1978. The residential area is Hill Hill Village, which is easily accessible across the river from Vietnam. Discussion 1 The family has reported the phenomenon of family clustering of nasopharyngeal carcinoma. There are more nasopharyngeal cancers among siblings among the cancer family members. This belongs to this category of twin nasopharyngeal carcinoma brothers. In addition, her mother also has nasopharyngeal cancer, which is related to dominant genetics, pending further study. 2 The clinical symptoms and examination results of the twin children with nasopharyngeal carcinoma