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血小板反应蛋白（ TSP）是一种重要的细胞外基质糖蛋白，包括 TSP-1、TSP-2、TSP-3、TSP-4和软骨寡聚基质蛋白／TSP-5五种类型。其中TSP-1由血小板α颗粒、成纤维细胞、血管内皮细胞等分泌，在病理及生理情况下可发挥多种生物学作用（如抑制血管内皮细胞增殖和迁移、促进血小板激活和聚集等），且与多种疾病的发生、发展密切相关。近年来，TSP-1在多种肾脏疾病中的作用日益引起人们的关注。“,”Thrombospondins(TSPs) are important matricellular glycoproteins.The TSP family consists of 5 members,TSP-1,TSP-2,TSP-3,TSP-4 and COMP/TSP-5.TSP-1 is secreted by a variety types of cells such as platelet alpha granule,fibroblast and endothelial cell,which is found to play a variety of biological roles in pathological and physiological conditions.TSP-1 can inhibit the proliferation and migration of vascular endo-thelial cells,promote platelet activation and aggregation ,and is closely related with the occurrence and devel-opment of many kinds of diseases.Recently,the role of TSP-1 in a variety of kidney diseases has attracted increasing attention.