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目的:探讨胰岛素样生长因子m RNA结合蛋白3(IMP3)在胰腺癌组织中的表达及其临床意义。方法:用免疫组化法检测126例胰腺癌组织以及12例正常胰腺组织中的IMP3表达,分析IMP3表达与胰腺癌患者临床病理因素及预后的关系。结果:胰腺癌组织中IMP3的阳性表达率明显高于正常胰腺组织(93.65%vs.0.00%,P<0.000)。IMP3的表达水平与胰腺癌患者的肿瘤大小、淋巴结转移、肿瘤侵袭深度、TNM分级有关(均P<0.05);IMP3高表达患者的中位生存时间明显低于IMP3低表达患者(9.5个月vs.17.8个月,P=0.000)。结论:IMP3在胰腺癌组织中表达率增高,且其表达水平与胰腺肿瘤的发生、发展密切相关,IMP3高表达患者预后不良。
Objective: To investigate the expression of insulin-like growth factor-m RNA binding protein 3 (IMP3) in pancreatic carcinoma and its clinical significance. Methods: The expression of IMP3 in 126 pancreatic cancer tissues and 12 normal pancreatic tissues was detected by immunohistochemistry. The relationship between IMP3 expression and the clinicopathological parameters and prognosis of pancreatic cancer was analyzed. Results: The positive expression rate of IMP3 in pancreatic cancer was significantly higher than that in normal pancreatic tissue (93.65% vs.0.00%, P <0.000). The expression of IMP3 was correlated with tumor size, lymph node metastasis, tumor invasion depth and TNM grade (P <0.05). The median survival time of IMP3 overexpression was significantly lower than that of IMP3 overexpression (9.5 months vs .17.8 months, P = 0.000). Conclusion: The expression of IMP3 in pancreatic cancer tissues is increased, and its expression level is closely related to the occurrence and development of pancreatic neoplasms. The poor prognosis of IMP3 overexpression patients.