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铝对脑和骨组织的毒性,已有不少临床报道。在一些肾衰竭患者中,输入铝可造成致死性神经原综合症,透析脑病和尿毒症患者发生的一种独特的骨营养不良症亦与这种脑病相关。铝负荷过多主要出现在肾功能减退的病人,但在一些曾于全静脉营养(TPN)中输入铝的肾功能正常病人中,也发现铝引起的骨病。至今,铝盐仍广泛用作药物,其中许多作为长期口服用药,含铝抗酸药仍被列为最广泛使用的非处方药。
Aluminum toxicity to the brain and bone tissue, there are many clinical reports. In some patients with renal failure, aluminum exposure causes a unique form of osteodystrophy that occurs in patients with Fatal Neuropathic Syndrome, Dialysis Encephalopathy, and Uremia, also associated with this encephalopathy. Aluminum overload occurs predominantly in patients with impaired renal function, but aluminum-induced bone disease is also found in some patients with normal renal function who have been exposed to aluminum in total parenteral nutrition (TPN). To date, aluminum salts are still widely used as medicines, many of which are still among the most widely used over-the-counter medicines as long-term oral medications.