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缺钾和低血钾是临床上常见的症候,它既是某些疾病的重要表现,又可由一些药物所引起。对慢性缺钾的治疗,口服补充钾盐实为不可缺少的重要措施。口服补钾,以往均以氯化钾溶液为主,但味咸涩,且可引起胃部刺激,以致难以长期坚持服用。国外近十余年来,曾陆续用氯化钾肠溶片、泡腾钾片、枸椽酸钾、醋酸钾、葡萄糖酸钾溶液等,来代替氯化钾溶液。虽部分解决了涩味及胃部刺激等问题,但氯化钾肠溶片可引起肠道溃疡;泡腾钾和葡萄糖酸钾溶液等无氯离子,而低钾症常同时缺氯,故疗效不佳。一九六五年以来有报导将氯化钾嵌在惰性蜡状骨架及塑料骨架中的新剂型,称为缓释钾片。此片型在胃肠道缓慢释放氯化钾,基本上不引起口腔及胃部刺激,也使小肠溃疡等并发症大大减少。有人曾比较氯化钾溶液与骨架型片的生物利用度,指出,两种不同剂型的120小时尿钾净增量无显著差
Potassium deficiency and hypokalemia are common clinical symptoms, it is not only an important manifestation of some diseases, but also caused by some drugs. The treatment of chronic potassium deficiency, potassium salt is an indispensable addition of important measures. Oral potassium, potassium chloride solution in the past are based, but the taste salty astringent, and can cause stomach irritation, resulting in difficult to adhere to long-term use. Nearly 10 years abroad, have been using potassium chloride enteric-coated tablets, effervescent potassium tablets, potassium citrate, potassium acetate, potassium gluconate solution, instead of potassium chloride solution. Although part of the solution to astringency and gastric irritation and other issues, but enteric-coated tablets of chloride can cause intestinal ulcers; effervescent potassium and potassium gluconate solution without chlorine ions, and hypokalemia often at the same time, so the effect of chlorine Poor. It has been reported since 1965 that a new dosage form of potassium chloride embedded in an inert waxy skeleton and a plastic skeleton is called a sustained release potassium tablet. The film slow release of potassium chloride in the gastrointestinal tract, basically does not cause mouth and stomach irritation, but also greatly reduce complications such as small bowel ulcers. Some people have compared the bioavailability of potassium chloride solution and matrix-type tablets, pointed out that two different formulations of 120-hour urine potassium net increment was no significant difference