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胰岛素依赖型糖尿病(Insulin-Dependent DiabetesMellitus,IDDM)被认为是一个自身免疫性疾病。其发生和发展同胰岛β细胞的免疫耐受性丧失和免疫效应机制选择性破坏胰岛β细胞有关。并且细胞免疫和体液免疫都参与了这一过程。因此,胰岛β细胞自抗原和由它产生的自抗体始终是IDDM免疫发病学研究的焦点。现就此方面予以综述:
Insulin-dependent diabetes mellitus (IDDM) is considered an autoimmune disease. Its occurrence and development with the loss of pancreatic β-cell immune tolerance and immune response mechanisms selectively damage islet β cells. And cellular immunity and humoral immunity are involved in this process. Thus, islet β-cell self-antigens and self-antibodies produced by them are always the focus of IDDM immunological epidemiology. Now we summarize this aspect: