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目的比较应用缩宫素注射液肌内注射与缩宫素鼻喷雾剂喷鼻用于第三产程预防产后出血的效果及药物的不良反应。方法将自然分娩初产妇100例随机分为对照组和观察组各50例,对照组于胎儿娩出后即刻肌内注射缩宫素注射液10个单位,观察组于胎儿娩出后即刻用缩宫素鼻喷雾剂对产妇两侧鼻孔各喷入1喷(每喷0.1 ml相当4单位),比较两组产妇产后2 h及24 h出血量、用药后全身及局部不良反应、第三产程时间。结果两组产妇用药后2 h及24 h阴道出血量,第三产程时间比较差异无统计学意义(P>0.05);对照组用药后43例产妇出现注射部位疼痛,8例恶心,3例呕吐;观察组用药后4例产妇恶心,无呕吐发生,不良反应发生率对照组高于观察组,差异有统计学意义(P<0.05)。结论两组产妇产后出血量及第三产程的时间均无明显差异,缩宫素肌内注射组全身及局部不良反应发生率高于缩宫素鼻喷雾剂组。
Objective To compare the effects of oxytocin injection with oxytocin nasal spray nasal spray for the prevention of postpartum hemorrhage in the third stage of labor and drug adverse reactions. Methods 100 cases of primipara of spontaneous childbirth were randomly divided into control group and observation group of 50 cases. In the control group, 10 units of oxytocin injection were intramuscularly injected immediately after the fetus was delivered. The observation group was treated with oxytocin Nasal spray on the nostrils on both sides of the nose were injected into a spray (0.1 ml per spray equivalent 4 units), two groups of postpartum 2 h and 24 h postpartum hemorrhage, systemic and local adverse drug reactions, the third stage of labor time. Results There was no significant difference in the vaginal bleeding volume and the third stage of labor between the two groups at 2 h and 24 h (P> 0.05). In the control group, 43 maternal women had injection site pain, 8 nausea and 3 vomiting In the observation group, nausea and vomiting occurred in 4 maternal women. The incidence of adverse reactions in the observation group was higher than that in the observation group (P <0.05). Conclusions There was no significant difference in postpartum hemorrhage volume and the third stage of labor among the two groups. The incidence of systemic and local adverse reactions in oxytocin intramuscular injection group was higher than that of oxytocin nasal spray group.