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测定４０例风心病患者和２４例正常人血浆组织型纤溶酶原激活物（ｔＰＡ）及其抑制物（ＰＡＩ－１）活性。结果表明：风心病患者ｔＰＡ活性较对照组明显降低，ＰＡＩ－１则明显升高；且风心病合并房颤者ｔＰＡ活性明显低于无房颤者，ＰＡＩ－１则明显高于无房颤者。提示风心病患者存在纤溶功能的障碍，合并房颤者尤为严重。
The plasma level of tissue plasminogen activator (tPA) and its inhibitor (PAI-1) were determined in 40 patients with rheumatic heart disease and 24 normal subjects. The results showed that the activity of tPA in patients with rheumatic heart disease was significantly lower than that in the control group and PAI-1 was significantly increased; tPA activity in patients with rheumatic heart disease and atrial fibrillation was significantly lower than those without AF, while PAI-1 was significantly higher than those without AF . Prompt fibrinolytic patients with fibrinolytic disorders, combined with atrial fibrillation is particularly serious.