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目的探讨阿托伐他汀对糖尿病肾病患者肾脏的保护作用。方法将信阳市第二人民医院2007年10月至2010年10月收治的72例糖尿病肾病患者随机分为两组,两组均给予糖尿病的常规治疗,治疗组在常规治疗基础上加用阿托伐他汀20 mg/d,每晚顿服,连续服用3个月。结果治疗组的总胆固醇、甘油三酯、低密度脂蛋白胆固醇均较治疗前有显著下降,与对照组相比较差异有统计学意义(P<0.05);两组24 h尿蛋白排泄率、血肌酐、尿素氮较治疗前均有所下降,治疗组较对照组下降更为显著(P<0.05)。结论阿托伐他汀能明显减少糖尿病肾病患者的尿蛋白排泄,延缓肾损害的发展进程,从而更好地发挥肾脏保护作用。
Objective To investigate the protective effects of atorvastatin on the kidney of patients with diabetic nephropathy. Methods The 72 patients with diabetic nephropathy admitted to the Second People’s Hospital of Xinyang from October 2007 to October 2010 were randomly divided into two groups. Both groups were given conventional treatment of diabetes. The treatment group was treated with ATO Statin 20 mg / d, Dayton clothing every night, taking 3 consecutive months. Results The total cholesterol, triglyceride and low density lipoprotein cholesterol of the treatment group were significantly lower than those of the control group (P <0.05), and the urinary protein excretion rate of 24 h Creatinine, urea nitrogen than before treatment decreased, the treatment group decreased more significantly than the control group (P <0.05). Conclusions Atorvastatin can significantly reduce urinary protein excretion and delay the development of renal damage in patients with diabetic nephropathy, so as to better exert renal protective effect.