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分别用部颁试标、部颁正标和以人工肠液为溶出介质的浆法测得尼莫地平片的溶出度,分别与其体内的生物利用度进行相关性研究。结果表明,按部颁试标测定的溶出度与生物利用度呈无显著性负相关,按部颁正标测定的溶出度与生物利用度呈无显著性正相关,而若采用人工肠液为溶出介质,则所得溶出度与生物利用度呈显著的正相关,即采用人工肠液为溶出介质最为合理。
The dissolution rates of nimodipine tablets were respectively measured by the ministerial bidding, the ministry standard and the artificial intestinal juice as the dissolution medium, and their bioavailability were studied respectively. The results showed that there was no significant negative correlation between the dissolution rate and the bioavailability determined by the ministry’s award. There was no significant positive correlation between the dissolution rate and the bioavailability determined by the ministry standard. However, if the artificial intestinal juice was used as the dissolution Medium, then the resulting dissolution and bioavailability was significantly positively correlated, that is, the use of artificial intestinal juice as the dissolution medium is the most reasonable.