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目的评价BEOP方案治疗复发难治性弥漫大B细胞淋巴瘤近期疗效及不良反应。方法 25例复发难治性弥漫大B细胞淋巴瘤行BEOP方案2周期化疗,平阳霉素6 mg/m2肌注,d1、d4、d8、d11,依托泊苷60 mg/m2/d,静滴,d1～5,VCR 1.4 mg/m2静注,d1,PDN 20 mg每日2次,d1～14。每4个星期为1个周期并重复,2个周期后观察疗效。结果完全缓解(CR)6例,部分缓解(PR)10例,稳定(SD)5例,进展4例,总有效率(CR+PR)为64.0%,不良反应主要为骨髓抑制及低热等,3级以上白细胞减少16.0%,血小板减少4.0%,行粒细胞集落刺激因子或白细胞介素-11支持治疗后恢复正常,发热经对症处理好转,胃肠道及神经炎症状亦较轻。结论 BEOP方案治疗复发难治性弥漫大B细胞淋巴瘤疗效肯定,不良反应小,骨髓抑制不严重,耐受性较好。
Objective To evaluate the short-term curative effect and adverse reactions of BEOP regimen in relapse-refractory diffuse large B cell lymphoma. Methods 25 cases of relapsed and refractory diffuse large B cell lymphoma were treated with 2 cycles of BEOP regimen. Bleomycin 6 mg / m 2 intramuscular injection, d1, d4, d8, d11 and etoposide 60 mg / m2 / d, , d1 ~ 5, VCR 1.4 mg / m2 intravenous injection, d1, PDN 20 mg twice daily, d1 ~ 14. Every 4 weeks for a cycle and repeat, observe the effect after 2 cycles. Results 6 cases were complete remission (CR), 10 cases were partial remission (PR), 5 cases were stable (SD), 4 cases were progressive. The total effective rate was 64.0%. The adverse reactions were mainly myelosuppression and hypothermia. Grade 3 leukopenia 16.0%, thrombocytopenia 4.0%, granulocyte colony stimulating factor or interleukin-11 support and treatment returned to normal, fever by the symptomatic treatment of gastrointestinal and neurological symptoms are mild. Conclusions The BEOP regimen is effective in treating recurrent refractory diffuse large B cell lymphoma with little adverse reaction, less severe bone marrow suppression and better tolerability.