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建立氯地滴眼液中,氯霉素和地塞米松磷酸钠的双波长比值光谱测定法。用Excel绘制氯霉素和地塞米松磷酸钠的比值光谱,选择比值光谱的峰点(或谷点)和交点作为测定波长对,能有效地消除共存组分的干扰,以实现对被测组分的准确测定。在选定的实验条件下,氯霉素和地塞米松磷酸钠在5.0 mg/L～50.0 mg/L范围内,其线性关系良好,平均回收率分别为100.3%、101.5%,相对标准偏差(RSD)分别为0.71%、0.59%。该方法简便、快速、重现性好,可用于氯地滴眼液的质量控制。
The establishment of chlorine eye drops, chloramphenicol and dexamethasone sodium phosphate dual wavelength ratio spectrometry. Using Excel to plot the ratio spectra of chloramphenicol and dexamethasone sodium phosphate, choosing the peak (or valley) and the intersection of the ratio spectra as the measuring wavelength pair can effectively eliminate the interference of the coexisting components, Accurate determination of points. Under the selected experimental conditions, the linearity of chloramphenicol and dexamethasone sodium phosphate in the range of 5.0 mg / L to 50.0 mg / L was good with the average recoveries of 100.3% and 101.5%, respectively. The relative standard deviations RSD) were 0.71% and 0.59% respectively. The method is simple, rapid, reproducible and can be used for the quality control of chlorine eye drops.