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高致病性猪链球菌2型的致病机制仍是未解之谜。毒力岛不仅赋予病原菌特殊的致病能力,而且在细菌的适应性进化过程中扮演重要角色。对猪链球菌2型89K毒力岛功能性基因的深入剖析有助于更全面地掌握病原菌的致病特性。综述了猪链球菌2型89K毒力岛的结构与进化过程,以及国内外对毒力岛中二元信号转导系统、IV型分泌系统、ABC转运蛋白、毒素-抗毒素系统等重要基因的研究进展,力图从基因水平为猪链球菌2型的致病机制寻找突破口。
The pathogenic mechanism of the highly pathogenic Streptococcus suis type 2 remains unexplored. Virulent islands not only give pathogenic bacteria a special pathogenic capacity, but also in the adaptive evolution of bacteria play an important role. In-depth analysis of the functional genes of Streptococcus suis type 2 89K virulence island will help to more fully grasp the pathogenesis of pathogenic bacteria. The structure and evolution of Type 2 89K virulence island of Streptococcus suis were reviewed as well as the studies of important genes such as binary signal transduction system, type IV secretion system, ABC transporter and toxin-antitoxin system in virulent island at home and abroad Progress, trying to find a breakthrough from the genetic level for the pathogenesis of Streptococcus suis type 2.