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【目的】研究 p5 3、p2 1和bcl 2基因蛋白在舌鳞状细胞癌组织中的表达及其临床意义。【方法】用免疫组化SP法检测 5 4例舌鳞状细胞癌组织标本p5 3、p2 1和bcl 2癌基因蛋白表达。【结果】舌鳞状细胞癌组织中p5 3、p2 1和bcl 2蛋白阳性率分别为 46 %、6 1%、46 % ;p5 3和 p2 1蛋白表达与肿瘤细胞分化程度及颈淋巴结转移有关 (P <0 0 5 ) ;p5 3蛋白表达与 p2 1蛋白表达有关 (P <0 0 5 ) ,bcl 2基因蛋白表达与 p5 3或p2 1基因蛋白表达无关 (P >0 0 5 )。【结论】舌鳞状细胞癌组织中具有较高的 p5 3、p2 1和bcl 2癌基因蛋白表达 ;p5 3和 /或p2 1蛋白阳性病例恶性程度高 ,易发生颈淋巴结转移。p5 3和 /或 p2 1蛋白可作为舌鳞癌预后的参考指标
【Objective】 To investigate the expression of p5 3, p21 and bcl2 in tongue squamous cell carcinoma and its clinical significance. 【Methods】 The expressions of p5 3, p21 and bcl2 oncoproteins in 54 specimens of tongue squamous cell carcinoma were detected by immunohistochemical SP method. 【Results】 The positive rates of p5 3, p21 and bcl2 protein in tongue squamous cell carcinoma were 46%, 61% and 46% respectively. The expressions of p5 3 and p21 protein were correlated with the degree of tumor cell differentiation and cervical lymph node metastasis (P <0.05). The expression of p53 protein was related to the expression of p21 (P <0.05). The expression of bcl2 gene was not related to the expression of p5 3 or p21 (P> 0.05). 【Conclusions】 Squamous cell carcinoma of tongue has high expression of p5 3, p21 and bcl2 oncogene proteins. The positive cases of p5 3 and / or p21 protein are highly malignant and prone to cervical lymph node metastasis. p5 3 and / or p2 1 protein can be used as a reference indicator of tongue squamous cell carcinoma prognosis