100例脑梗死患者血小板糖蛋白Ⅰbα基因多态性测定及临床意义的研究

• 作 者: 戚其学 许大义 曹云鹏
• 机 构: 中国医科大学附属第一医院神经免疫室,沈阳医学院沈洲医院检验科,中国医科大学附属第一医院神经内科 辽宁沈阳110001,辽宁沈阳110035,辽宁沈阳110001
• 出 处: 中国血液流变学杂志
• 发表日期: 2007年04期
• 关键词: 脑梗死 血小板糖蛋白Ⅰbα 多态性

目的探讨血小板糖蛋白Ⅰbα基因HPA2多态性在脑梗死发病中的作用。方法以分子生物学技术采用PCR方法测定100脑梗死患者与正常对组血小板糖蛋白Ⅰbα基因HPA2多态性。结果100例脑梗死患者组、大动脉粥样硬化型脑梗死患者组及小动脉闭塞型脑梗死患者组(TOAST分型)与相应对照组之间GPⅠbαHPA2基因型频率的分布差异无显著性;大动脉粥样硬化型中杂合突变型比例(16.1%)要高于小动脉闭死型中杂合突变型比例(10.1%),但差异无显著意义。结论GPⅠbαHPA2基因杂合突变型可能并非是脑梗死的危险因素。

Objective To investigate the role of platelet glycoprotein Ⅰ bα gene HPA2 polymorphism in the pathogenesis of cerebral infarction. Methods Polymerase chain reaction was used to determine the HPA2 polymorphism of platelet glycoprotein Ⅰ bα gene in 100 patients with cerebral infarction and normal controls by molecular biology techniques. Results There were no significant differences in the frequencies of GP Ⅰ bαHPA2 genotypes among the 100 patients with cerebral infarction, the patients with large atherosclerotic cerebral infarction and the patients with arterial occlusive cerebral infarction (TOAST) and the corresponding controls. The proportion of heterozygous mutant type in the sclerosis type (16.1%) was higher than that of the heterozygous mutant type in the arteriole closure type (10.1%), but the difference was not significant. Conclusion The heterozygous mutant GP Ⅰ bα HPA2 gene may not be the risk factor of cerebral infarction.