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目的通过对92例药物性肝病的临床特点及危险因素的分析,提高基层医务工作者对该病的认识,做到规范临床用药,提高诊治率,减少发病率。方法根据1997年欧洲药物性肝病M aria诊断评分标准,以最后判断≥14分的92份病例的综合资料进行回顾性调查统计分析。结果使用抗结核类药、抗生素类药、中药及中成药的病例,与未使用这类药物的病例进行比较,其M aria分值在统计学上存在显著差异(P<0.05)。而在年龄、性别组的M aria分值比较,存在显著差异(P<0.05),有无饮酒嗜好组的M aria分值比较,存在极显著差异(P<0.01)。结论诱发药物性肝病的前3位药物,主要是抗结核类药、抗生素类药、中药及中成药,男性、中老年病人和有饮酒嗜好的易患药物性肝病。基层临床医务工作者在实际工作中应加强药物和肝功能监测,加强药物的使用指导和预防宣传,减少发病率。
Objective To analyze the clinical characteristics and risk factors of 92 cases of drug-induced liver disease, and to improve the understanding of the disease among grassroots medical workers so as to standardize clinical medication, improve the diagnosis and treatment rate and reduce the incidence. Methods According to the diagnostic criteria of M aria in European drug-induced liver disease in 1997, the comprehensive data of 92 cases with a final score of ≥14 were retrospectively analyzed. Results There were statistically significant differences in the M aria scores between anti-tuberculosis drugs, antibiotics, traditional Chinese medicines and proprietary Chinese medicines, compared with those who did not use these drugs (P <0.05). There was significant difference (P <0.05) in M aria score between age and sex group, and there was significant difference (P <0.01) between M aria score of drinking or not. Conclusions The first three drugs induced by drug-induced liver disease are mainly anti-tuberculosis drugs, antibiotics, traditional Chinese medicines and proprietary Chinese medicines, men, middle-aged and elderly patients and susceptible drug-induced liver diseases with alcohol consumption. In the practical work, grassroots clinical medical workers should strengthen drug and liver function monitoring, strengthen guidance and prevention of drug use, and reduce the incidence.