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对5例眼眶MALT恶性淋巴瘤(均为男性,平均年龄55.4岁)进行临床病理、免疫组化及形态定量测定研究。标本采用常规石蜡切片,HE染色及ABC法免疫组化染色,用HPIAS-1000彩色图像分析系统对肿瘤细胞核的形态进行定量测定。5例均为小淋巴细胞型恶性淋巴瘤,免疫组化染色瘤细胞表达均为LCA和L26阳性,形态定量测定表明肿瘤细胞与对照组间14项参数具有高度显著性差异(p<0.001)。说明免疫组化染色及形态定量测定对眼眶恶性淋巴瘤的诊断和鉴别诊断具有重要意义,形态定量测定为眼眶恶性淋巴瘤疑难病例的诊断提供了一种新的重要辅助诊断方法。
Five cases of orbital MALT malignant lymphoma (both men, mean age 55.4 years) were studied by clinicopathological, immunohistochemical and morphometric analysis. The paraffin sections were stained with HE and ABC immunohistochemical staining. The morphology of tumor nuclei was quantitatively determined by HPIAS-1000 color image analysis system. All the 5 cases were small lymphocytic malignant lymphoma. Immunohistochemical staining of tumor cells showed LCA and L26 positive. Morphometric analysis showed that there were 14 highly significant differences (p <0.001) between the tumor cells and the control group. Immunohistochemical staining and morphometric determination of orbital malignant lymphoma diagnosis and differential diagnosis of great significance, morphometry quantitative determination of difficult cases of orbital malignant lymphoma diagnosis provides a new important ancillary diagnostic method.