Fast Electrical Detection of Carcinoembryonic Antigen Based on AlGaN/GaN High Electron Mobility Tran

• 作 者: 占香蜜 王权 王琨 李巍 肖红领 冯春 姜丽娟 王翠梅 王晓亮 王占国
• 机 构: Key Lab of Semiconductor Materials Science,Institute of Semiconductors,Chinese Academy of Sciences,S
• 出 处: Chinese Physics Letters
• 发表日期: 2017年09期
• 关键词: AlGaN colorectal drain seriously Electron gated transistor instead Antigen adeno

As one of the most important tumor-associated antigens of colorectal adenocarcinoma, the carcinoembryonic antigen(CEA) threatens human health seriously all over the globe. Fast electrical and highly sensitive detection of the CEA with AlGaN/GaN high electron mobility transistor is demonstrated experimentally. To achieve a low detection limit, the Au-gated sensing area of the sensor is functionalized with a CEA aptamer instead of the corresponding antibody. The proposed aptasensor has successfully detected different concentrations(ranging from 50 picogram/milliliter(pg/ml) to 50 nanogram/milliliter(ng/ml)) of CEA and achieved a detection limit as low as 50 pg/ml at V_(ds) = 0.5 V. The drain-source current shows a clear increase of 11.5μA under this bias.

As one of the most important tumor-associated antigens of colorectal adenocarcinoma, the carcinoembryonic antigen (CEA) threatens human health seriously all over the globe. Fast electrical and highly sensitive detection of the CEA with AlGaN / GaN high electron mobility transistor is demonstrated experimentally. The proposed aptasensor has successfully detected different concentrations (ranging from 50 picogram / milliliter (pg / ml) to 50 nanogram / milliliter (ng / ml)) of CEA and achieved a detection limit as low as 50 pg / ml at V ds = 0.5 V. The drain-source current shows a clear increase of 11.5 μA under this bias.