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目的 :研究烟碱 (nicotine)、可乐定(clonidine)单、复方透皮给药的戒烟作用。方法 :建立大鼠口服烟碱形成依赖性病理模型 ,用烟碱和 /或可乐定透皮吸收制剂作戒断治疗。结果 :(1 )烟碱小剂量治疗轻型烟瘾有效 ,大剂量治疗重型烟瘾无效 ;(2 )可乐定小剂量治疗轻瘾效果较差 ,大剂量治疗重瘾效果较好 ;(3 )复方烟碱与可乐定透皮给药小剂量治疗轻瘾、大剂量治疗重瘾的效果最佳。结论 :复方烟碱与可乐定透皮给药治疗烟碱依赖性 (烟瘾 )有显著协同效果。
Objective: To study the effects of nicotine, clonidine alone and compound transdermal drug on smoking cessation. Methods: The rat model of oral nicotine-dependent pathology was established and treated with nicotine and / or clonidine transdermal absorption preparation. The results showed that: (1) low doses of nicotine were effective in treating light-type smoking and high-dose in treating heavy-type smoking was ineffective; (2) low-dose of clonidine was less effective in light-addiction and heavy- And Colaidine transdermal delivery of small doses of light addiction, high-dose treatment of heavy addiction the best. CONCLUSIONS: The combination of nicotine and clonidine transdermally has a significant synergistic effect on nicotine dependence (addiction).