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目的：探讨硫酸镁辅助治疗顽固性癫癎的剂量、方法及疗效。方法：治疗组72例，用25%硫酸镁10 mL静脉滴注，或用16.5%硫酸镁10 mL口服。对照组36例给予常规抗癫癎药物，卡马西平或苯妥英钠加苯巴比妥或氯硝西泮加用γ-氨基丁酸等治疗。结果：治疗组有效率87.5%，对照组有效率44.4%，两组比较经统计学分析P＜0.01，差异极显著。结论：硫酸镁联合一线抗癫癎药治疗顽固性癫癎的方法简单易行，具有良好效果。“,”Objective:To determine the dosage,method and effectiveness of using magnesium sulfate for treating the intractable epilepsy.Methods:72 cases were allocated to treatment group and 36 to control group. For those in the treatment group,either 10 mL of 25% MgSO4 was administered by intravenous drip or 10 mL of 16.5% MgSO4 by oral intake once per day,in addition to the use of the commonly used antiepilepsy drugs. For those in the control group,the commonly used antiepilepsy drugs such as tegretol,sodium phenytoin,luminal or γ-Aminobutyric Acid were employed.Results:The improvement rate in the treatment group was 87.50%,higher than that (44.44%) in the control group (P＜0.01).Conclusion:Using magnesium sulfate in conjunction with the antiepilepsy drugs is a simple yet effective regime for the treatment of the intractable epilepsy.