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目的：评价大剂量免疫球蛋白（ＩＶＩＧ） 治疗格林巴利综合征（ＧＢＳ） 的临床效果。方法：对４２ 例符合急性ＧＢＳ 的患儿进行临床分型，随机对２２ 例患儿采用ＩＶＩＧ 治疗，按４００ ｍｇ／ｋｇ·ｄ ，连用３ ～７ ｄ ；对照组选用冰冻血浆治疗，按１０ ｍｌ／ｋｇ·ｄ ，连用３ ～７ ｄ 。结果：两组患儿７５ ％ 以上有前驱感染史，在临床症状和体征方面两组无明显差异性，在发病至入院时间上亦无明显差异，但在症状出现至最虚弱时间和最虚弱至症状开始改善时间，两组在统计学上存在显著性差异（ Ｐ 分别为＜０－０１） 。观察组在滴注ＩＶＩＧ 后２４ ～４８ ｈ 病情稳定不再进展，３ ～５ ｄ 肌力开始恢复，最早者从发病至四肢肌力达０ ～Ⅰ度伴重度呼吸困难，但到病程第１０ ～１２ 天可搀扶下地活动，平均住院天数为１７－８６ ±４－７０（９ ～２６）ｄ ，对照组为２２－３９ ±７－６７（１０ ～３２）ｄ（ Ｐ＜ ０－０５） 。ＩＶＩＧ 组无１ 例行气管切开，未发现１ 例毒副反应，１１ 例患儿随访６ 个月～２ 年，未见复发及神经系统后遗症发生。结论：ＩＶＩＧ 治疗ＧＢＳ 可缩短病程，使病人迅速度过呼衰危险期，进入恢复期，早期及连续１ 周应用效果更佳。ＩＶＩＧ 较血浆治疗安全
Objective: To evaluate the clinical efficacy of high-dose immunoglobulin (IVIG) in the treatment of GBS. Methods: Forty-two children with acute GBS were enrolled in this study. Twenty-two children were randomized to IVIG treatment at 400 mg / kg · d for 3-7 days. In the control group, frozen plasma was used and 10 ml / Kg · d, once every 3 to 7 d. Results: Over 75% of the children in both groups had a history of prodromal infection. There was no significant difference in clinical symptoms and signs between the two groups. There was no significant difference between the onset and the admission time. However, when the symptoms appeared to the weakest and the weakest Symptoms began to improve, and there was a statistically significant difference between the two groups (P <0-01, respectively). Observed group 24-48 hours after instillation of IVIG stable condition no longer progress, 3 ~ 5 d muscle strength began to recover, the earliest onset to the limbs muscle strength of 0 ~ Ⅰ degree with severe breathing difficulties, but the course of 10 ~ The average length of hospital stay was 17-86 ± 4-70 days (9-26 days), while the control group was 22-39 ± 7-67 days (10-32 days) (P <0-05). There was no one case of tracheotomy in IVIG group. One case of toxic side effects was not found and 11 cases were followed up for 6 months to 2 years. No recurrence and neurological sequelae occurred. Conclusion: The treatment of GBS by IVIG can shorten the course of the disease, make the patients quickly pass the risk of respiratory failure, and enter the convalescence stage. The application of IVIG in early and continuous one week is better. IVIG is more safe than plasma treatment