论文部分内容阅读
迄今为止从动物脑内发现的内源性吗啡样物质已达20余种,均为肽类物质,分属于脑啡肽、内啡肽和强啡肽三个系统。曾有报告发现了内源性非肽类的吗啡样物质(如镇痛素),但未经后人证实。1984年7月在英国剑桥举行的国际麻醉性镇痛药研究学会上,美国斯坦福大学药理系教授、成瘾药物研究所所长A.哥德斯坦报告,应用吗啡的抗体作放射免疫测定,从牛脑和垂体中检出了吗啡样活性。他们
So far, more than 20 endogenous morphine-like substances have been found in the brain of animals, all of which are peptides, belonging to enkephalin, endorphin and dynorphin three systems. It has been reported that endogenous non-peptide morphine-like substances (such as anthraxides) have been reported, but have not been confirmed. July 1984 at the International Society of Narcotic Analgesics Research Institute held in Cambridge, England Stanford University Department of Pharmacology, Professor A. Gerstein, director of Institute of Addiction Drugs report, the application of morphine antibodies for radioimmunoassay, from Morphine-like activity was detected in bovine brain and pituitary gland. they