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10名患脑膜炎和/或败血症的婴儿,经常规的抗菌治疗(例如卡那霉素、氨苄青霉素、磺胺类药物)失败后,应用增效新明磺(SMZ+SMz)联合治疗,获得了满意的疗效。 10名患儿的年龄为从生后8天到10个月,其中有6例患儿的月龄未超过1个月。有7例婴儿从脑脊液或血液分离出固紫阴性杆菌,其中1例同时有金黄色葡萄球菌感染。有1例婴儿分离出白色葡萄球菌,有2例患儿的病原体未确定。所有患儿均根据抗菌素敏感试验结果注射抗菌素,其中有4例疗程超过10天。除2例外,所有患儿均曾同时加用磺胺异二甲基嘧啶(Sulfaisodimidine)。当患儿开始换用增效新明磺治疗时,从4例固紫阴性细菌感染和1例金黄色葡萄球菌败血症仍能培养出细菌。其他患儿的培养结果虽为阴性,但从临床情况、脑脊液检查、白细胞计数和C反应蛋白来判断,感染尚未控制。
Ten infants with meningitis and / or sepsis who received combination therapy with neostigmine (SMZ + SMz) after failure of conventional antimicrobial therapy (eg, kanamycin, ampicillin, sulfonamides) Satisfactory results. The age of 10 children ranged from 8 days to 10 months after birth, of which 6 children did not exceed 1 month of age. In 7 infants, solid-violet-negative bacilli were isolated from cerebrospinal fluid or blood, of which 1 had S. aureus infection at the same time. One infant isolated Staphylococcus aureus, and two children had undetermined pathogens. All patients were given antibiotics based on results of the antibiotic susceptibility test, of which 4 were treated for more than 10 days. With the exception of 2 cases, all children had been treated with Sulfaisodimidine. When the children started to switch to the use of synergistic neostigmine treatment, bacterial colonization was still possible from 4 cases of solid-violet-negative bacterial infection and 1 case of Staphylococcus aureus septicemia. Although other children’s culture results negative, but judging from the clinical situation, cerebrospinal fluid examination, white blood cell count and C-reactive protein, infection has not yet been controlled.