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目的分析抗生素临床规范用药干预对医院病原菌耐药性改变趋势的影响,探讨其临床价值。方法收集无锡市锡山人民医院2014年1月至2015年12月住院患者标本分离的2 155株病原菌,比较实施抗生素临床规范用药干预前后抗生素使用种类、强度、病原菌检出率、病原菌耐药性变化,分析病原菌耐药性改变趋势。结果与2014年比较,2015年抗生素品种、抗生素使用强度均下降。干预措施实施后,革兰阳性菌对阿莫西林、克林霉素耐药性显著降低,革兰阴性菌对头孢他啶、氨曲南、亚胺培南耐药性显著降低(P<0.05)。结论多科室联动的抗生素临床规范用药干预措施可有效提高抗生素使用的合理性,降低部分病原菌耐药性。
Objective To analyze the influence of antibiotic clinical norms intervention on the change trend of hospital pathogenic bacteria drug resistance and to explore its clinical value. Methods A total of 2 155 strains of pathogens isolated from hospitalized patients from January 2014 to December 2015 were collected from Xishan People’s Hospital of Wuxi City. The types of antibiotics used before and after the intervention of antibiotics, the detection rate of pathogens, the change of pathogenic bacteria resistance , Analysis of pathogenic bacteria drug resistance change trend. Results Compared with 2014, the antibiotic varieties and antibiotic use intensity dropped in 2015. After the implementation of the interventions, the resistance of gram-positive bacteria to amoxicillin and clindamycin was significantly reduced. The resistance of gram-negative bacteria to ceftazidime, aztreonam and imipenem was significantly reduced (P <0.05). Conclusion Intervention with multidisciplinary antibiotics clinical norms medication interventions can effectively improve the rational use of antibiotics and reduce the resistance of some pathogens.