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目的:观察早产儿原发性呼吸暂停应用纳洛酮治疗的疗效。方法:将60例早产儿原发性呼吸暂停患儿随机分为观察组和对照组各30例,两组在常规治疗的基础上均应用氨茶碱注射液,同时观察组加用纳洛酮注射液,静脉推注每次0.1mg/kg,每隔8h给药1次。结果:观察组总有效率96.67%,对照组总有效率76.67%,两组比较差异有统计学意义(χ2=5.19,P<0.05),且两组均未发现与药物有关的不良反应。结论:早产儿原发性呼吸暂停应用纳洛酮治疗可提高疗效,效果优于单用氨茶碱,且无不良反应发生。
Objective: To observe the efficacy of naloxone in the treatment of premature infants with primary apnea. Methods: 60 cases of premature infants with primary apnea were randomly divided into observation group and control group, 30 cases in both groups on the basis of routine treatment with aminophylline injection, while the observation group plus naloxone Injection, intravenous injection of 0.1mg / kg, administered once every 8h. Results: The total effective rate was 96.67% in the observation group and 76.67% in the control group. The difference between the two groups was statistically significant (χ2 = 5.19, P <0.05). No drug-related adverse reactions were found in both groups. Conclusion: Naloxone treatment can improve the efficacy of primary apnea in preterm infants, the effect is better than single aminophylline, and no adverse reactions occur.