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目的探讨2型糖尿病(T2DM)患者微量白蛋白尿(MAU)与心血管危险因素的相关性。方法 T2DM患者483例,根据尿白蛋白与肌酐比值(ACR)分为正常白蛋白尿组(A组,248例,ACR<30mg/g)和MAU组(B组,235例,ACR 30-300mg/g)。检测两组血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2-h血糖(PBG)、空腹胰岛素(FIns)。结果与A组比较,B组TG、TC、LDL-C、FBG、PBG、FIns均明显增加(P<0.05);高血压病、冠心病、动脉粥样硬化的发病率升高(P<0.05)。体重指数、收缩压、TC、FBG是发生MAU的独立危险因素。结论 T2DM患者MAU易合并超重、高血压、糖脂代谢紊乱,心血管疾病风险增加。
Objective To investigate the correlation between microalbuminuria (MAU) and cardiovascular risk factors in type 2 diabetes mellitus (T2DM). Methods 483 T2DM patients were divided into normal albuminuria group (A group, 248 cases, ACR <30mg / g) and MAU group (B group, 235 cases, ACR 30-300mg) according to the urinary albumin to creatinine ratio (ACR) / g). The serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) , Postprandial 2-h blood glucose (PBG), fasting insulin (FIns). Results Compared with group A, the levels of TG, TC, LDL-C, FBG, PBG and FIns in group B were significantly increased (P <0.05); the incidence of hypertension, coronary heart disease and atherosclerosis increased ). Body mass index, systolic blood pressure, TC, FBG are independent risk factors for the occurrence of MAU. Conclusions The MAU in patients with T2DM is easily associated with overweight, high blood pressure, dyslipidemia, and increased risk of cardiovascular diseases.