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目的:针对赛霉安乳膏中冰片含量不稳定问题,对其中一主药成分冰片稳定性进行改进.方法:采用饱和溶液搅拌法用β-环糊精将主药冰片进行包合,通过均匀设计优化出最佳包合条件.结果:通过实验选取了最佳包合条件为主客分子比9∶1、温度45℃、搅拌速度900 r·min-1、搅拌时间4.5h,通过薄层色谱及红外色谱验证形成了稳定的包合物.结论:本方法成功制备了相对稳定的冰片的β环糊精包合物.“,”Objective:To improve the stability of one of the main active composition borneol for solving the instability of meisaian cream.Methods:Borneol-β-cyclodextrin inclusion was prepared by saturated solution mixing method and the best experiment conditions were obtained by orthogonal experiments.Results:The optimal preparation conditions for inclusion were as follows:the ratio of borneol and β-cyclodextrin as 9∶ 1,at 45 ℃ for 4.5 h,and stirring speed at 900 r· min-1 The inclusion complex was identified by thin layer chromatography (TLC) and infrared spectra analysis methods.Conclusion:The relatively stable borneol-β-cyclodextrin inclusion compound has been successfully achieved by our method.