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本文应用微量稀释法研究了２４名施硬膜内手术患者应用头孢曲松（ＣＴＲＸ）、头孢噻肟（ＣＴＸ）和头孢呋肟（ＣＦＲ）后血清和脑脊液杀菌效价（ＳＢＡ与ＣＢＡ）。结果表明，其中ＣＴＲＸ对肠杆菌科细菌的体内外抗菌活性最强，在脑脊液中的杀菌效价也较高，维持时间长，从而提示一日２次，每次１ｇ静脉给药，可望有效防治严重的肠杆菌科细菌所致颅脑手术后感染；ＣＴＸ对革兰氏阳性球菌及肠杆菌科细菌的杀菌效价均较高，可用于防治颅脑混合细菌感染；ＣＦＲ在脑脊液中杀菌作用软弱，但抗菌谱广，价格偏低，可用于预防一般颅脑手术感染；本文发现ＣＢＡ是一项能反映抗菌药物对细菌的作用和对血脑屏障通透性的重要指标，故建议将ＣＢＡ作为选择抗菌药物防治颅脑手术感染的重要参考依据。
In this paper, the serum and cerebrospinal fluid (CeBA and CBA) bactericidal efficacy of ceftriaxone (CTRX), cefotaxime (CTX) and cefuroxime (CFR) in 24 patients undergoing epidural operation were studied by microdilution method. The results showed that CTRX had the strongest antibacterial activity against Enterobacteriaceae both in vitro and in vivo, and its bactericidal titer in cerebrospinal fluid was also high for a long time, which suggested that intravenous administration of 1 g twice daily could be effective Prevention and treatment of Enterobacteriaceae severe craniocerebral infection caused by bacteria; CTX against Gram-positive cocci and enterobacteriaceae bactericidal titers are higher, can be used for prevention and treatment of mixed brain infections; CFR bactericidal effect in cerebrospinal fluid Weak, but broad antibacterial spectrum, the price is low, can be used to prevent general craniocerebral infection; CBA is a reflection of the role of antibacterial drugs on the blood-brain barrier permeability and an important indicator, it is proposed CBA As an important reference for choosing antimicrobial agents to prevent craniocerebral infection.