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目的探讨控释前列腺素E2栓-普贝生在孕晚期引产中的作用。方法对50例无前列腺禁忌、单胎头位、胎膜未破、妊娠37~≥42周,有引产指征的孕妇,将普贝生一枚横置于阴道后穹窿深处作为实验组(A组),另选50例同样条件的孕妇,用0.5%的催产素静脉点滴为对照组(B组),比较两组的Bishop评分、引产效果、用药至临产时间、剖宫产率、新生儿窒息率?产后出血。结果A组能有效提高Bishop评分,有效率88%,B组24%,差异有统计学意义(P<0.01);引产成功率A组86%,B组68%(P<0.01);用药至临产时间A组平均(23.4±9.2)h,B组(43.7±15.8)h(P<0.01);A组剖宫产率低于B组(P<0.01);而新生儿窒息率?产后出血及副反应无明显差别。结论普贝生可安全、方便、有效的用于孕晚期引产。
Objective To investigate the role of controlled release prostaglandin E2 suppository in the third trimester of pregnancy. Methods 50 pregnant women with no prostate taboo, single head position, unperforated fetal membranes and 37 ~ 42 weeks of gestation were included in the study. Group A). Another 50 pregnant women of the same condition were selected and treated with intravenous 0.5% oxytocin as control group (Group B). The Bishop score, induction effect, medication to labor time, cesarean section rate, freshmen Child suffocation rate? Postpartum hemorrhage. Results The Bishop score was improved in group A, the effective rate was 88% and that in group B was 24%, the difference was statistically significant (P <0.01); the success rate of induced labor in group A was 86% in group B and 68% in group B (P <0.01) The average time of labor was 23.4 ± 9.2 h in group A, and 43.7 ± 15.8 h in group B (P <0.01). The cesarean section rate in group A was lower than that in group B (P <0.01), while the rate of neonatal asphyxia postpartum hemorrhage And no significant difference between side effects. Conclusion Pubei students can be safe, convenient and effective for the second trimester induction of labor.