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作者评价了小剂量心房利钠因子(Atrial Natriaretic Fator;ANF)对慢性充血性心力衰竭患者的心肾作用。 16例Ⅲ或Ⅳ级充血性心力衰竭患者。其中特发性心脏病7例、高血压性6例、缺血性2例、瓣膜返流性1例。研究结果表明,给予ANF后尿流量(每分钟0.81±0.06 L到1.81±0.23 ml,p<0.01)、钠排泄率(每分钟56±14 L到80±23μEq,p<0.01),钠分数排泄率(1.23±0.49L到1.63±0.60%,p<0.01)、钾排泄率(每分钟35±7 L到42±6μEq,p<0.02)均有显著增加。然而,肾血浆流量或肾小球滤过率未见显著改变。再者,尿流量或钠排泄率改变与肾血浆流速或肾小球滤过率改变无显
The authors evaluated the cardiac and renal effects of low-dose atrial natriuretic factor (ANF) in patients with chronic congestive heart failure. 16 cases of grade Ⅲ or Ⅳ patients with congestive heart failure. Among them, 7 cases were idiopathic heart disease, 6 cases were hypertension, 2 cases were ischemic and 1 case was valvular regurgitation. The results showed that the urinary excretion rate (56 ± 14 L to 80 ± 23 μEq per minute, p <0.01), the excretion of sodium fraction (0.81 ± 0.06 L to 1.81 ± 0.23 ml, p <0.01) The rate of potassium excretion (35 ± 7 L to 42 ± 6 μEq per minute, p <0.02) increased significantly from 1.23 ± 0.49L to 1.63 ± 0.60%, p <0.01. However, there was no significant change in renal plasma flow or glomerular filtration rate. Again, changes in urinary flow or sodium excretion were not associated with changes in renal plasma flow or glomerular filtration rate