实验性铅中毒母子两代肾脏病理改变

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肾脏是铅毒性作用的主要靶器官。本文试图从大鼠铅中毒模型的肾病理学改变,追踪铅在母子两代肾脏中分布及其对肾脏的毒性作用,为铅的生殖毒理学提供依据。一、材料与方法雌性Wistar成年大鼠24只,随机分为四组。Ⅰ组腹腔注射硝酸铅溶液10mg/kg,5天1次。Ⅱ组硝酸铅溶液80mg/kg灌胃,3天1次。Ⅲ组水中加入 Kidneys are the main target organ of lead toxicity. This article attempts to trace the renal pathology of lead poisoning model in rats, to track the distribution of lead in the kidney of the two generations of mother and its toxic effects on the kidneys, and provide the basis for reproductive toxicology of lead. First, materials and methods Female Wistar adult rats 24 were randomly divided into four groups. Group Ⅰ intraperitoneal injection of lead nitrate solution 10mg / kg, 5 days 1 time. Group Ⅱ lead nitrate solution 80mg / kg gavage, 3 days 1 time. Ⅲ group of water added
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