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目的 :评价白花前胡对慢性炎症性肺动脉高压的防治效果 ,探讨肺循环血液流变学特征的改变在肺动脉高压形成中的作用。方法 :采用野百合碱 (monocrotoline,MCT)诱导的慢性炎症性肺动脉高压大鼠模型 ;白花前胡 (5 0 ,10 0 ,15 0mg·kg-1/d)采用管饲给药 3周 ;治疗效果的评价采用血流动力学 (肺动脉平均压 )、血液流变学(表观及还原粘度、红细胞聚积指数 )及相关性分析。结果 :白花前胡可分别使MCT诱导的肺动脉高压降低14.5 %、19.2 % (P <0 .0 5 )、18.8% (P <0 .0 5 )。白花前胡 (10 0mg·kg-1/d)能有效降低大鼠MCT组肺循环血液高切 (2 0 0 /s)表观粘度 2 3.9% (P <0 .0 5 )、低切 (1/s)表观粘度 39.6 % (P <0 .0 1)和红细胞聚积指数 15 .7% (P <0 .0 5 )。其降低表观粘度 (2 0 0 /s ,1/s)与其降低肺动脉压间的相关系数分别是 0 .86 8(P <0 .0 5 )、0 .6 35 (P <0 .0 5 )。结论 :白花前胡能通过改善肺微循环 ,有效降低慢性炎症性肺动脉高压大鼠升高的肺动脉压
Objective: To evaluate the control effect of Peucedanum praeruptorum on chronic inflammatory pulmonary hypertension and to explore the role of changes in the hemorheology of pulmonary circulation in the formation of pulmonary hypertension. METHODS: A rat model of chronic inflammatory pulmonary hypertension induced by monocrotoline (MCT) was administered; Baihua Qian Hu (50, 100, 150 mg·kg-1/d) was administered by gavage for 3 weeks; The effects were assessed using hemodynamics (average pulmonary artery pressure), hemorheology (apparent and reduced viscosity, erythrocyte accumulation index), and correlation analysis. RESULTS: Baihua Qianhu reduced MCT-induced pulmonary hypertension by 14.5%, 19.2% (P <0.05), and 18.8% (P <0.05), respectively. Baihua Qianhu (10 0 mg·kg-1/d) can effectively reduce the high-cut (2 0 0 /s) apparent viscosity of pulmonary blood circulation in the MCT group to 3.9% (P < 0.05) and low-cut (1) /s) The apparent viscosity was 39.6 % (P < 0.01) and the erythrocyte accumulation index was 15.7% (P <0.05). The correlation coefficient between the decrease of apparent viscosity (200/s, 1/s) and the decrease of pulmonary artery pressure was 0.886 (P <0.05), 0.65 (P <0.05). ). Conclusion : Baihua Qian Hu can effectively reduce pulmonary artery pressure in rats with chronic inflammatory pulmonary hypertension by improving pulmonary microcirculation