论文部分内容阅读
胰岛素样生长因子1型受体(IGF-1R)是一种跨膜酪氨酸蛋白激酶,它在多数肿瘤细胞中均有过量表达,形成并维持肿瘤细胞的转化表型,参与细胞的增殖和分化,与肿瘤细胞的浸润性生长和转移密切相关。有研究表明人肝癌细胞HepG2中 IGF-1R呈现高表达。我们应用前期筛选出的、能够显著抑制
Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane tyrosine kinase that is overexpressed in most tumor cells to form and maintain the transformed phenotype of tumor cells and is involved in cell proliferation and Differentiation is closely related to the invasive growth and metastasis of tumor cells. Studies have shown that human hepatocellular carcinoma cells HepG2 IGF-1R showed high expression. Our application pre-screening, can significantly inhibit