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目的报告手部A族链球菌(group A streptococcus,GAS)感染导致的中毒性休克综合征(toxic shock syndrome,TSS)的临床特点和治疗方法。方法对2004年1月-2005年9月收治的6例急性手部GAS感染导致的TSS患者,进行综合治疗。结果综合治疗2周后,4例患者完全治愈,伤口全部愈合,手功能恢复好。2例患者遗留轻度的手指关节僵硬,总TAM减少40°～60°,心、肝脏器轻度损害。3～6个月后随访,其中1例上述症状已完全愈合,手功能恢复好；另1例总TAM减少20°。结论GAS的生物学特性决定了TSS的临床特点和致病机理,应针对其生物学特性予以积极治疗。
Objective To report the clinical characteristics and treatment of toxic shock syndrome (TSS) caused by group A streptococcus (GAS) infection. Methods Six patients with TSS caused by acute hand GAS infection were treated in our hospital from January 2004 to September 2005. Results After 2 weeks of comprehensive treatment, 4 patients were completely cured, all the wounds healed, and hand function recovered well. 2 patients left mild joint stiffness, total TAM reduced 40 ° ~ 60 °, heart, liver damage. After 3 to 6 months follow-up, one of the above symptoms had completely healed, and the hand function recovered well; in the other case, the total TAM was reduced by 20 °. Conclusion The biological characteristics of GAS determine the clinical features and pathogenesis of TSS, and should be actively treated according to its biological characteristics.