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甲状腺是内分泌器官,受促甲状腺素(TRH)的调节,这种作用通过甲状腺腺体的胞浆膜上受体(Receptor)而实现。1956年,Adams和Purves发现甲状腺机能亢进病人血清中存在一种自身抗体,称长效促甲状腺素(LATS),也是通过TSH的膜受体发挥作用。因此,甲状腺胞浆膜受体是研究甲状腺生理和疾病的重要课题。本文简要讨论甲状腺胞浆膜受体和甲状腺刺激抗体。 一、TSH受体 Smith和Hall(1974)建立放射受体分析法,系采用手术切除的甲状腺制成组织匀浆提取TSH受体,再用人或牛的TSH来阻断
The thyroid gland is an endocrine organ that is regulated by thyrotropin (TRH), and this effect occurs through the cytoplasmic membrane receptors on the thyroid gland. In 1956, Adams and Purves found that there is an autoantibody in the sera of patients with hyperthyroidism, called long-acting thyrotropin (LATS), which also acts through membrane receptors of TSH. Therefore, thyroid cytoplasmic receptor thyroid physiology and disease research is an important issue. This article briefly discusses thyroid cytoplasmic receptors and thyroid stimulating antibodies. TSH Receptors Smith and Hall (1974) established a radioreceptor assay using a surgically excised thyroid tissue homogenate to extract TSH receptors and then blocked with human or bovine TSH