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日前《科学》杂志上的2篇报告显示,设计用来抑制2种特定酶——IDH1和IDH2的变异小分子可分别减缓白血病和脑肿瘤细胞的生长。这些发现提示,以IDH1和IDH2酶(这些酶的变异被认为与许多癌症有关)为标靶可产生新的诱使癌性细胞分化的治疗策略。首先,Fang Wang及其同事描述了一种被称为AGI-6780的小分子,它能抑制变异形式的IDH2基因。研究人员展示了该分子与IDH2的变异复合的一
Two recent reports in Science showed that small variants designed to inhibit two specific enzymes, IDH1 and IDH2, slow down the growth of leukemia and brain tumor cells, respectively. These findings suggest that a novel therapeutic strategy to induce cancerous cell differentiation may be generated by targeting IDH1 and IDH2 enzymes, which variants are thought to be associated with many cancers. First, Fang Wang and colleagues described a small molecule called AGI-6780 that inhibits the mutant form of the IDH2 gene. The researchers demonstrated a complex of this molecule with IDH2