论文部分内容阅读
实验报道了心肌细胞团自发性同步化搏动的一类新节律——整数倍节律。这种稳定的节律模式由两种相关的搏动形式的随机交替出现形成,这两种搏动形式中任何一种的出现间期具有整数倍特征。在静息状态和周期1搏动间的随机交替形成0-1整数倍节律,在周期1搏动和周期2搏动之间的随机交替形成1-2整数倍节律。0-1整数倍是居于静息状态和周期1节律之间的节律模式,1-2整数倍是居于周期1节律和周期2节律之间的节律模式,实验所见的节律转迁过程清楚地展示了静息状态、0-1整数倍节律、周期1节律、1-2整数倍节律、周期2节律等顺序地构成的一种“节律谱系”。“节律谱系”的观念可以为认识正常和异常心律的关系和其间的转迁机制提供深刻的理论启示。
The experiment reports a new type of rhythm, an integral multiple of rhythm, in spontaneous synchronized pulsations of cardiomyocytes. This stable rhythmic pattern is formed by the random alternation of two related beating patterns, with the occurrence interval of any one of these two beating patterns being an integral multiple. The random alternation between resting state and periodic 1 beats forms an integral rhythm of 0-1, forming a 1-2 integer law of rhythms at random alternation between cycle 1 beats and cycle 2 beats. An integer multiple of 0-1 is a rhythm pattern that rests between the resting state and the cycle 1 rhythm. An integer multiple of 1 to 2 is a rhythm pattern that resides between the cycle 1 rhythm and the cycle 2 rhythm. The rhythm transfer process observed experimentally clearly Shows a “rhythm lineage” consisting of resting states, an integer rhythm of 0-1, a rhythm of period 1, an integer rhythm of 1-2, a rhythm of period 2, and the like. The concept of “rhythm pedigree” can provide profound theoretical enlightenment for understanding the relationship between normal and abnormal heart rhythm and the transfer mechanism between them.