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目的通过对心力衰竭(HF)患者血清锌离子(Zn)浓度的分析,探讨Zn浓度与HF的相关性,为HF的治疗提供新的依据。方法选取于2015年7-9月于天津医科大学总医院心血管内科住院的HF患者187例作为研究对象,并入选63例无器质性心血管疾病者作为对照组,分别调查性别、年龄、吸烟史,进行身高、体重、血压的测量,并进行超声心动检查,检测N端脑利钠肽前体(NT-pro BNP)、Zn浓度、血肌酐、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和空腹血糖。应用SPSS 21.0软件对数据进行t检验、χ2检验、Mann-Whitney U检验和方差分析,用logistic回归和线性回归分析Zn与HF的相关性。结果 HF组患者Zn浓度[627.55(503.69,785.89)μg/L]明显低于对照组[699.08(562.68,815.41)μg/L],差异有统计学意义(P<0.01),HF组患者NT-pro BNP水平[1 963.25(1 066.10,4 654.31)ng/L]明显高于对照组[92.17(50.76,220.90)ng/L],差异有统计学意义(P<0.01)。logistic回归分析结果显示,在校正年龄、血肌酐、甘油三酯和空腹血糖后,第2三分位数组(Zn浓度为598.54~774.37μg/L)Zn浓度与HF患病之间有相关性(OR=0.61,95%CI:0.39~0.97,P=0.04)。线性回归分析结果显示,HF患者的Zn浓度与NT-pro BNP呈负相关(β=-0.08,P=0.02),且在校正年龄和血肌酐后结果仍有统计学意义(β=-0.08,P=0.03)。结论血清Zn浓度与HF有关,并且与HF的严重程度呈负相关,这可能有助于进一步揭示HF患者病理生理的变化,并且有可能为HF的新治疗方法提供依据。
Objective To investigate the relationship between Zn concentration and HF in serum of patients with heart failure (HF), and to provide a new basis for the treatment of HF. Methods A total of 187 HF patients hospitalized in the Department of Cardiology, Tianjin Medical University General Hospital from July to September 2015 were selected as the study subjects. 63 patients without organic cardiovascular diseases were enrolled as the control group, and their gender, age, Smoking history, height, weight, blood pressure and echocardiography. NT-pro BNP, Zn concentration, serum creatinine, total cholesterol, triglyceride, low density lipoprotein Protein cholesterol, high-density lipoprotein cholesterol and fasting blood sugar. The data were analyzed by t-test, χ2 test, Mann-Whitney U test and analysis of variance with SPSS 21.0 software. The correlation between Zn and HF was analyzed by logistic regression and linear regression. Results The concentration of Zn in the HF group was significantly lower than that in the control group [627.55 (503.69, 7885.89) μg / L [699.08 (562.68, 815.41) μg / L, P 0. 01) The level of pro BNP [1 963.25 (1066.104 654.31) ng / L] was significantly higher than that of the control group [92.17 (50.76, 220.90) ng / L]. The difference was statistically significant (P <0.01). Logistic regression analysis showed that after adjusting for age, serum creatinine, triglyceride and fasting blood glucose, there was a correlation between Zn concentration in the second tertile (Zn concentration of 598.54-774.37μg / L) and the prevalence of HF ( OR = 0.61, 95% CI: 0.39-0.97, P = 0.04). Linear regression analysis showed that the concentration of Zn in HF patients was negatively correlated with NT-pro BNP (β = -0.08, P = 0.02), and there was still a significant difference after adjusting for age and serum creatinine (β = -0.08, P = 0.03). Conclusions Serum Zn concentration is related to HF and negatively correlated with the severity of HF, which may be helpful to further reveal the pathophysiological changes in patients with HF, and may provide a basis for the new treatment of HF.