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采用先制微丸再包控释膜的方法制备头孢氨苄缓释微丸 ,装入胶囊。体外释放试验表明 ,所制缓释胶囊在酸性与碱性介质中的释药速度基本一致 ,均符合Higuchi模型。经加速试验 ,质量稳定
Preparing cefotaxime sustained-release pellets by the method of preparing the first pellets and then releasing the controlled release film and filling the capsules. The in vitro release test showed that the release rate of the sustained-release capsules in acid and alkaline media was basically the same, all in line with the Higuchi model. After accelerated testing, quality and stability