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目的研究骨桥蛋白(OPN)在非小细胞肺癌(NSCLC)中的表达。方法应用组织芯片免疫组织化学方法检测226例肺癌组织(无淋巴结转移116例,淋巴结转移110例)和25例正常肺组织中OPN的表达,并进行比较分析。结果226例肺癌组织中OPN表达阳性84例(37.2%),其中51例为有淋巴结转移的肺癌组织,33例为无淋巴结转移的肺癌组织;正常肺组织中无OPN表达。结论OPN在有淋巴结转移的NSCLC组织中表达增高,提示其在NSCLC的转移中起重要作用。
Objective To study the expression of osteopontin (OPN) in non-small cell lung cancer (NSCLC). Methods Tissue microarray immunohistochemistry was used to detect the expression of OPN in 226 lung cancer tissues (116 without lymph node metastasis, 110 with lymph node metastasis) and 25 normal lung tissues. Results The positive expression of OPN in 226 cases of lung cancer was 84 (37.2%), of which 51 cases were lung cancer with lymph node metastasis and 33 cases were lung cancer without lymph node metastasis. The expression of OPN was not found in normal lung tissues. Conclusion The expression of OPN is increased in NSCLC with lymph node metastasis, suggesting that OPN plays an important role in the metastasis of NSCLC.