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目的探讨整合素连接激酶(ILK)在宫颈上皮内瘤变(CIN)及宫颈癌组织中的表达及临床意义。方法2000年1月至2007年12月在沧州中西医结合医院采用免疫组化技术(S-P法)检测ILK在99例宫颈CIN和宫颈癌中的表达。结果ILK在正常宫颈黏膜上皮、CINⅠ～Ⅱ级、CINⅢ级、浸润癌表达的阳性率分别为26.7%、72.0%、80.0%、97.9%。各级CIN与浸润癌相比ILK的表达率差异有统计学意义(P<0.05)。ILK表达率与临床分期及病理分级有关(P<0.05)。结论ILK可作为反映宫颈上皮增生病变程度及生物学行为的指标,对宫颈非浸润性病变与浸润性病变的诊断及鉴别有参考价值。
Objective To investigate the expression and clinical significance of integrin - linked kinase (ILK) in cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods From January 2000 to December 2007, immunohistochemistry (S-P method) was used to detect the expression of ILK in 99 cases of cervical CIN and cervical cancer in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine. Results The positive rates of ILK expression in normal cervical mucosal epithelium, CIN Ⅰ ~ Ⅱ grade, CIN Ⅲ grade, invasive carcinoma were 26.7%, 72.0%, 80.0% and 97.9% respectively. The expression of ILK in all levels of CIN was significantly different from that of invasive carcinoma (P <0.05). The expression of ILK was correlated with clinical stage and pathological grade (P <0.05). Conclusion ILK can be used as an index to reflect the degree and biological behavior of cervical epithelial hyperplasia. It has reference value for the diagnosis and identification of cervical non-invasive lesions and infiltrative lesions.