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目的:比较促红细胞生成素(EPO)联合金脑放疗(WBRT)与单纯WBRT治疗伴有贫血的非小细胞肺癌(NSCLC)脑转移的疗效。方法:伴有贫血的NSCLC脑转移患者68例分为两组:对照组36例行单纯WBRT,联合组32例自WBRT开始使用EPO至放疗结束。观察两组疗效的差异。结果:联合组与对照组近期有效率分别为84.4%与61.1%,生活质量改善率为81.3%与58.3%,神经系统症状缓解率为87.5%与66.7%,急性放射性脑损伤发生率为28.1%与52.8%,两组比较差异有统计学意义(P<0.05)。结论:对伴有贫血的NSCLC脑转移患者WBRT期间使用EPO,可改善贫血,提高放疗疗效,保护脑组织,改善患者生活质量。
Objective: To compare the efficacy of erythropoietin (EPO) combined with golden brain irradiation (WBRT) and simple WBRT in the treatment of brain metastases associated with anemia in non-small cell lung cancer (NSCLC). METHODS: Sixty-eight patients with anemia-associated NSCLC brain metastases were divided into two groups: 36 in the control group treated with simple WBRT, and 32 in the combined group treated with EPO from WBRT until the end of radiotherapy. To observe the difference between the two groups. Results: The effective rates of the combined group and the control group were 84.4% and 61.1%, the quality of life improvement was 81.3% and 58.3%, the rate of nervous system symptom relief was 87.5% and 66.7% respectively, and the incidence of acute radiation brain injury was 28.1% And 52.8%, the difference between the two groups was statistically significant (P <0.05). Conclusion: The use of EPO during WBRT in patients with brain metastases of NSCLC accompanied with anemia can improve anemia, improve the curative effect of radiotherapy, protect brain tissue and improve the quality of life of patients.