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目的:研究MK-447对胶原、ADP及血栓素A_2稳定类似物(STA_2)诱导的血小板变形、聚集和释放反应的影响。方法:浊度法评价血小板变形和聚集反应,测定富含血小板血清中ATP的量确定释放反应。结果:(1)MK-447诱导血小板变形,不被吲哚美辛抑制。预置MK-447可使胶原、ADP及STA_2的血小板变形能力下降,时程延长。(2)MK-447抑制胶原的聚集反应,并使ADP和STA_2聚集增强。(3)胶原和STA_2的释放反应可被MK-447抑制和增强。MK-447对STA_2的作用与S-145无关。结论:血小板变形在其激活早期发挥重要作用。MK-447诱导血小板变形,并对不同聚集剂的作用表现为抑制和增强的双重影响。
AIM: To investigate the effects of MK-447 on platelet aggregation, release and release induced by collagen, ADP and ST 2 -like analogues (STA 2). Methods: Turbidity method was used to evaluate platelet deformability and aggregation, and the amount of ATP in platelet rich serum was determined to determine the release response. Results: (1) MK-447 induced platelet deformity and was not inhibited by indomethacin. Pre-set MK-447 collagen, ADP and STA_2 platelet deformability decreased duration extended. (2) MK-447 inhibited the aggregation of collagen and enhanced the aggregation of ADP and STA_2. (3) The release of collagen and STA 2 can be inhibited and enhanced by MK-447. The effect of MK-447 on STA_2 is not related to S-145. Conclusion: Platelet degeneration plays an important role in its early activation. MK-447 induces platelet deformity and exhibits a dual effect of inhibition and enhancement on the effects of different aggregating agents.