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急性毒性实验表明:读书王胶囊LD_50未测出,小鼠最大耐受量(MTD)为84.0g生药/kg体重,该剂量为临床推荐用量的350倍,说明读书王胶囊是安全的.长期毒性试验给大鼠以4.8g生药/kg体重和12.0g生药/kg体重剂量连续灌胃60天(相当于临床推荐用药量的20~50倍).动物在试验期间的食量与体重呈同步增加,行为活动及大、小便未见异常改变.试验结束对大鼠进行血常规指标,肝、肾功能等6项生化指标检查均无明显异常.对其心、肝、肾、脾.肺、脑等12个重要脏器与组织的病理组织学检查亦未见明显毒性作用,脏器系数计算结果:各组间比较无显著性差异.提示该药长期口服基本安全无毒.
Acute toxicity test showed that RD_50 of Reading Wang capsule was not measured, and the maximum tolerated dose (MTD) of mice was 84.0g crude drug/kg body weight. This dose was 350 times the clinical recommended dosage, indicating that reading Wang capsule is safe. Long-term toxicity Rats were given a dose of 4.8 g crude drug/kg body weight and 12.0 g crude drug/kg body weight for 60 consecutive days (equivalent to 20 to 50 times the clinical recommended dosage). The animal’s food intake and body weight increased during the test. There were no abnormal changes in behavioral activities and urination. There were no significant abnormalities in blood biochemical indicators, hepatic and renal function tests in rats. The heart, liver, kidney, spleen, lungs, and brain were not found. The histopathological examination of 12 important organs and tissues also showed no obvious toxic effects. The calculation result of organ coefficient: There was no significant difference among the groups. It indicated that the drug was basically safe and non-toxic for long-term oral administration.