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目的探讨红细胞免疫相关表面分子CD35、CD55与疟疾感染的相关性。方法运用流式细胞术对桂西地区少数民族人群587例年龄20～75岁,平均年龄(43.27±14.55)岁曾经感染或者正在感染疟疾的患者和560例年龄20～72岁,平均年龄(44.86±13.81岁)健康成年人的红细胞表面分子CD35、CD55表达水平进行检测,探讨疟疾感染与红细胞免疫功能关系。结果疟疾易感者和非易感者红细胞CD35、CD55平均荧光强度差异均有统计学意义(均有P<0.001),疟疾易感者红细胞CD35、CD55分子的平均荧光强度均低于非易感者。结论红细胞表面分子CD35、CD55与疟疾感染有着较为密切的联系,为疟疾感染的诊断和治疗提供了新思路,其具体作用机制有待进一步研究。
Objective To investigate the correlation between erythrocyte immune related surface molecules CD35 and CD55 and malaria infection. Methods A total of 587 patients aged 20-75 years, mean age (43.27 ± 14.55), who had been infected with or infected with malaria and 560 males and females aged 20-72 years and mean age (44.86) were enrolled in this study. ± 13.81 years) healthy adults erythrocyte surface molecules CD35, CD55 expression levels were detected to explore the relationship between malaria infection and erythrocyte immune function. Results The average fluorescence intensity of CD35 and CD55 of erythrocytes in both susceptible and non-susceptible malaria patients were significantly different (all P <0.001). The mean fluorescence intensity of CD35 and CD55 in erythrocytes of susceptible malaria patients was lower than that of non- By. Conclusion Erythrocyte surface molecules CD35 and CD55 are closely related to malaria infection, providing new ideas for the diagnosis and treatment of malaria infection. The specific mechanism remains to be further studied.