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目的 研究铝氟联合暴露的电解铝工人神经行为功能的改变及其与铝、氟的接触水平 -效应关系 ,初步探讨神经毒作用机理。方法 采用WHO推荐的神经行为功能测试组合 (NCTB)对 6 5名电解铝工人和 5 2名对照工人进行测试 ,并测定其血浆铝氟浓度、谷胱甘肽过氧化物酶 (GSH -Px)活性、丙二醛 (MDA)含量及全血超氧化物歧化酶(SOD)活性、胆碱酯酶活性。结果 铝、氟浓度增高 ,GSH -Px活性降低 ,MDA含量增高 ,SOD活性增高 ,胆碱酯酶活性降低 (均P <0 0 0 1) ;NCTB的多数测试得分均有显著改变 ,且血浆氟浓度与数字跨度、提转敏捷度及情感状态得分间均存在明显相关。结论 电解铝作业可影响工人神经行为功能 ;血浆氟浓度与神经行为功能间存在一定接触水平-效应关系 ;在神经毒性方面 ,氟可能为电解铝作业的主要职业有害因素。
Objective To study the changes of neurobehavioral function and the level of exposure to aluminum and fluoride in electrolytic aluminum workers exposed to aluminum and fluorine, and to explore the mechanism of neurotoxicity. Methods Sixty five electrolytic aluminum workers and 52 control workers were tested by the NCTB. The levels of aluminum, fluoride, glutathione peroxidase (GSH-Px) Activity, malondialdehyde (MDA) content and whole blood superoxide dismutase (SOD) activity and cholinesterase activity. Results The concentrations of aluminum and fluoride increased, GSH-PX activity decreased, MDA content increased, SOD activity increased, and cholinesterase activity decreased (all P <0.01) Concentration and number of spans, transfer of agility and emotional state scores were significantly related. Conclusion Electrolysis of aluminum can affect workers’ neurobehavioral function. There is a certain level of contact-level effect between plasma fluoride concentration and neurobehavioral function. In terms of neurotoxicity, fluorine may be the major occupational hazardous factor in electrolytic aluminum operation.